This should be fine. Just make sure that your image partition size is small enough to fit on both. In other words, if one drive is 40GB and the other is 80 GB, you won’t be able to dump the 80GB partition image to the 40GB drive. You’d need to resize the partition first.
A fool-proof method for a one image for all scenario is to include the drivers for all your systems in the image and tell sysprep where the inf files are.
astrouga